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Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity.
Yu X, Tao J, Wu Y, Chen Y, Li P, Yang F, Tang M, Sammad A, Tao Y, Xu Y, Li YX. Yu X, et al. Diabetes Metab J. 2024 Feb 2. doi: 10.4093/dmj.2023.0124. Online ahead of print. Diabetes Metab J. 2024. PMID: 38310881 Free article.
METHODS: The constructed ASGR1 knockout mice and ASGR1-/- HepG2 cell lines were used to establish the animal model of metabolic syndrome and the IR cell model by high-fat diet (HFD) or drug induction, respectively. ...Notably, ASGR1 deficiency significantly r …
METHODS: The constructed ASGR1 knockout mice and ASGR1-/- HepG2 cell lines were used to establish the animal model of metaboli …
Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion.
Bongoni AK, Kiermeir D, Denoyelle J, Jenni H, Burlak C, Seebach JD, Vögelin E, Constantinescu MA, Rieben R. Bongoni AK, et al. Transplantation. 2015 Apr;99(4):693-701. doi: 10.1097/TP.0000000000000553. Transplantation. 2015. PMID: 25675194 Free article.
BACKGROUND: Asialoglycoprotein receptor-1 (ASGR1) mediates capture and phagocytosis of platelets in pig-to-primate liver xenotransplantation. ...METHODS: Porcine forelimbs were perfused with whole, heparinized human or autologous pig blood. Platelets were counted at regula …
BACKGROUND: Asialoglycoprotein receptor-1 (ASGR1) mediates capture and phagocytosis of platelets in pig-to-primate liver xenotranspla …